Carlson Brock M, Mitchell Blake A, Dougherty Kacie, Westerberg Jacob A, Cox Michele A, Maier Alexander
Department of Psychology, College of Arts and Science, Vanderbilt Vision Research Center, Center for Integrative and Cognitive Neuroscience, Vanderbilt University, Nashville, TN 37235, USA.
Department of Psychology, Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540, USA.
iScience. 2023 Jul 8;26(8):107359. doi: 10.1016/j.isci.2023.107359. eCollection 2023 Aug 18.
During binocular rivalry (BR) only one eye's view is perceived. Neural underpinnings of BR are debated. Recent studies suggest that primary visual cortex (V1) initiates BR. One trigger might be response suppression across most V1 neurons at the onset of BR. Here, we utilize a variant of BR called binocular rivalry flash suppression (BRFS) to test this hypothesis. BRFS is identical to BR, except stimuli are shown with a ∼1s delay. If V1 response suppression was required to initiate BR, it should occur during BRFS as well. To test this, we compared V1 spiking in two macaques observing BRFS. We found that BRFS resulted in response facilitation rather than response suppression across V1 neurons. However, BRFS still reduces responses in a subset of V1 neurons due to the adaptive effects of asynchronous stimulus presentation. We argue that this selective response suppression could serve as an alternate initiator of BR.
在双眼竞争（BR）期间，只能感知到一只眼睛的视野。BR的神经基础存在争议。最近的研究表明，初级视觉皮层（V1）启动了BR。一个触发因素可能是在BR开始时大多数V1神经元的反应抑制。在这里，我们利用一种称为双眼竞争闪光抑制（BRFS）的BR变体来测试这一假设。BRFS与BR相同，只是刺激显示有大约1秒的延迟。如果启动BR需要V1反应抑制，那么它也应该在BRFS期间发生。为了测试这一点，我们比较了两只观察BRFS的猕猴的V1神经元放电情况。我们发现，BRFS导致V1神经元的反应促进而不是反应抑制。然而，由于异步刺激呈现的适应性影响，BRFS仍然会降低一部分V1神经元的反应。我们认为这种选择性反应抑制可能是BR的另一种启动因素。
