Masse R, Fritsch P, Nolibé D, Sedaghat B
Pathol Biol (Paris). 1975 Jun;23(6):464-9.
The rat's alveolar macrophage population is a biological constant which significantly varies according to the season, the strain and the bacteriological state,in healthy animals. The percent rate of excreted macrophages remains constant in spite of the physiological changes of the total population variation. This rate is close to 3,5 %. So, the variations of the population are due to the changes in cell arrival. The possible different sources of alveolar macrophages are analysed and evaluated. The direct monocyte source is not sufficient to insure the stability of this population. Division of intra alveolar macrophage enables homeostasis. In pathological conditions, variations of cell populations result from two effects : reduction of excretion, positive or negative changes in cellular influx.
在健康动物中，大鼠的肺泡巨噬细胞数量是一个生物学常数，它会因季节、品系和细菌学状态而有显著变化。尽管巨噬细胞总数发生了生理变化，但排泄出的巨噬细胞的百分比仍保持恒定。这个百分比接近3.5%。因此，细胞数量的变化是由于细胞到达的变化所致。对肺泡巨噬细胞可能的不同来源进行了分析和评估。直接的单核细胞来源不足以确保该细胞群体的稳定性。肺泡内巨噬细胞的分裂可实现内环境稳定。在病理状态下，细胞群体的变化源于两种效应：排泄减少以及细胞流入的正向或负向变化。
