Blussé van Oud Alblas A, Mattie H, van Furth R
Cell Tissue Kinet. 1983 May;16(3):211-9.
A new mathematical approach to the calculation of the kinetics of macrophages in a tissue compartment is presented. This approach, which takes into account the influx of monocytes into the compartment, the local division of mononuclear phagocytes, and the efflux of macrophages from the compartment, was applied to data on the pulmonary macrophages of mice in the normal steady state. The results show that at least 70% of the pulmonary macrophage population is supplied by monocyte influx and at most 30% by local division of immature mononuclear phagocytes originating from the bone marrow. The calculated turnover time of pulmonary macrophages is about 6 days, and the turnover amounts to 14.6 X 10(3) macrophages/hr.
本文提出了一种计算组织隔室内巨噬细胞动力学的新数学方法。该方法考虑了单核细胞流入隔室、单核吞噬细胞的局部分裂以及巨噬细胞从隔室流出的情况，并应用于正常稳态下小鼠肺巨噬细胞的数据。结果表明，肺巨噬细胞群体中至少70%由单核细胞流入提供，至多30%由源自骨髓的未成熟单核吞噬细胞的局部分裂提供。计算得出肺巨噬细胞的周转时间约为6天，周转量为14.6×10³个巨噬细胞/小时。
