Brendel D H, Bodkin J A, Yang J M
Departments of Psychiatry and Laboratory Medicine, Massachusetts General Hospital, Boston, MA 02114-2698, USA.
Ann Emerg Med. 2000 Nov;36(5):524-6. doi: 10.1067/mem.2000.111575.
Selective serotonin reuptake inhibitor medications are considered relatively safe even in overdose. We report a massive overdose of sertraline with the highest serum sertraline concentration reported to date. Clinical features of this patient were confusion, agitation, myoclonus, hyperreflexia, fever, and creatine kinase elevation. This case may represent serotonin syndrome caused by sertraline overdose alone.
即使过量服用，选择性5-羟色胺再摄取抑制剂类药物也被认为相对安全。我们报告了一例舍曲林大量过量服用的病例，其血清舍曲林浓度为迄今报告的最高值。该患者的临床特征为意识模糊、烦躁不安、肌阵挛、反射亢进、发热及肌酸激酶升高。该病例可能仅由舍曲林过量导致血清素综合征。
