Al-Chaer E D, Kawasaki M, Pasricha P J
Division of Gastroenterology, Departments of Internal Medicine and Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, Texas 77555-0632, USA.
Gastroenterology. 2000 Nov;119(5):1276-85. doi: 10.1053/gast.2000.19576.
BACKGROUND & AIMS: The irritable bowel syndrome (IBS) is a common disorder characterized by abdominal pain in the setting of altered perception of viscerosensory stimuli. This so-called visceral hyperalgesia occurs in the absence of detectable organic disease in the peripheral organs and may cause normal or physiologic contractions to be perceived as painful. Although the pathogenesis of IBS remains speculative and is probably multifactorial, a prevailing paradigm is that transient noxious events lead to long-lasting sensitization of the neural pain circuit, despite complete resolution of the initiating event.
Neonatal male Sprague-Dawley rats received either mechanical or chemical colonic irritation between postnatal days 8 and 21 and were tested when they became adults. The abdominal withdrawal reflex and the responses of viscerosensitive neurons were recorded during colon distention.
Colon irritation in neonates, but not in adults, results in chronic visceral hypersensitivity, with characteristics of allodynia and hyperalgesia, associated with central neuronal sensitization in the absence of identifiable peripheral pathology.
These results concur largely with observations in patients with IBS, providing a new animal model to study IBS and validating a neurogenic component of functional abdominal pain that encourages novel approaches to health care and research.
肠易激综合征（IBS）是一种常见疾病，其特征为在内脏感觉刺激感知改变的情况下出现腹痛。这种所谓的内脏痛觉过敏在周围器官无可检测到的器质性疾病时发生，可能导致正常或生理性收缩被感知为疼痛。尽管IBS的发病机制仍具有推测性且可能是多因素的，但一个普遍的范式是，尽管引发事件已完全消退，但短暂的有害事件会导致神经疼痛回路的长期致敏。
新生雄性Sprague-Dawley大鼠在出生后第8天至第21天接受机械性或化学性结肠刺激，并在成年后进行测试。在结肠扩张期间记录腹部退缩反射和内脏感觉神经元的反应。
新生儿而非成年大鼠的结肠刺激会导致慢性内脏超敏反应，具有痛觉过敏和痛觉超敏的特征，在没有可识别的周围病理学情况下与中枢神经元致敏相关。
这些结果在很大程度上与IBS患者的观察结果一致，提供了一种新的动物模型来研究IBS，并验证了功能性腹痛的神经源性成分，这鼓励了新的医疗保健和研究方法。
