The clinical evaluation of prazosin, a new antihypertensive agent.

The hemodynamic and therapeutic profiles of prazosin have been delineated in a comprehensive clinical program involving more than 1,000 patients. Efficacy was established in double-blind placebo-controlled studies and open, noncomparative long-term studies and comparisons with standard antihypertensive agents. The efficacy and safety of prazosin make it particularly suitable for initiation and maintenance of long-term outpatient therapy for hypertension.