Smith I S, Fernandes M, Kim K E, Swartz C, Onesti G
Postgrad Med. 1975 Nov;Spec No:53-60.
A preliminary study of cardiac hemodynamics with measurement in both supine and tilt positions showed that the antihypertensive effect of prazosin given intravenously is associated with a fall in total peripheral resistance, with minor effects on cardiac output and heart rate, and with no consistent orthostatic hypotension. The postural reflexes appear to remain intact. The results are entirely similar to those reported by Lund-Johansen. In a second, short-term study of ambulatory patients, prazosin alone exerted an antihypertensive effect somewhat less than that of methyldopa, but the difference in blood pressure reduction between supine and standing positions was less with prazosin than with methyldopa. Both drugs were well tolerated. In a third, long-term study, prazosin alone gave satisfactory antihypertensive results, and prazosin used in combination with polythiazide produced a satisfactory response in 80% of the patients.
一项针对仰卧位和倾斜位心脏血流动力学测量的初步研究表明，静脉注射哌唑嗪的降压作用与总外周阻力下降有关，对心输出量和心率影响较小，且无持续的体位性低血压。体位反射似乎保持完整。结果与伦德 - 约翰森报道的完全相似。在第二项针对门诊患者的短期研究中，单独使用哌唑嗪的降压效果略低于甲基多巴，但哌唑嗪引起的仰卧位和站立位血压下降差异小于甲基多巴。两种药物耐受性均良好。在第三项长期研究中，单独使用哌唑嗪产生了令人满意的降压效果，哌唑嗪与多噻嗪联合使用使80%的患者产生了满意的反应。
