Stutzmann J, Bellissent-Waydelich A, Fontao L, Launay J F, Simon-Assmann P
INSERM Research Unit 381, Ontogenesis and Pathology of the Digestive System, 67200 Strasbourg, France.
Microsc Res Tech. 2000 Oct 15;51(2):179-90. doi: 10.1002/1097-0029(20001015)51:2<179::AID-JEMT9>3.0.CO;2-4.
This article review summarizes data on cell-substratum adhesion complexes involved in the regulation of cellular functions in the intestine. We first focus on the molecular composition of the two main adhesion structures-the beta1 integrin-adhesion complex and the hemidesmosome-found in vivo and in two human intestinal cell lines. We also report the key findings on the cellular behavior and response to the extracellular matrix that involve integrins, the main transmembrane anchors of these complexes. How the dynamics of cell/extracellular matrix interactions contribute to cell migration, proliferation, differentiation, and tumorigenicity is discussed in the light of the data provided by the human intestinal cells.
本文综述总结了有关参与肠道细胞功能调节的细胞-基质粘附复合物的数据。我们首先关注在体内以及两种人类肠道细胞系中发现的两种主要粘附结构——β1整合素-粘附复合物和半桥粒——的分子组成。我们还报告了关于涉及整合素（这些复合物的主要跨膜锚定蛋白）的细胞行为和对细胞外基质反应的关键发现。根据人类肠道细胞提供的数据，讨论了细胞/细胞外基质相互作用的动态过程如何促进细胞迁移、增殖、分化和肿瘤发生。
