Lussier C, Basora N, Bouatrouss Y, Beaulieu J F
MRC Group in Functional Development and Physiopathology of the Digestive Tract, Département d'anatomie et de biologie cellulaire, Faculté de médecine, Université de Sherbrooke, Sherbrooke, Qué., Canada.
Microsc Res Tech. 2000 Oct 15;51(2):169-78. doi: 10.1002/1097-0029(20001015)51:2<169::AID-JEMT8>3.0.CO;2-A.
The intestinal epithelium is a highly dynamic tissue, which depends on a variety of factors for the regulation of its rapid renewal and expression of digestive functions. Over the last 10 years, it has become evident that among these factors are cell interactions with the extracellular matrix, more specifically with the underlying basement membrane, through a series of specific cell membrane receptors, many of which are integrins. Integrins regulate the assembly of adhesive junctions as well as the activation of various signaling pathways, leading to the modulation of gene expression. The analysis of the integrin repertoire along the crypt-villus axis in the human small intestinal epithelium identifies a number of beta1 and beta4 integrins, showing differential patterns of expression relative to its two functional compartments. Among them are the integrins alpha3beta1, alpha7Bbeta1 and the functional form of alpha6beta4 that appear to be related, in concert with the distribution of their ligands, to the process of intestinal cell differentiation, and the integrins alpha2beta1, alpha1beta1, alpha5beta1, and the non-functional form of alpha6beta4 that seem to be coupled with the undifferentiated/proliferative status of crypt cells. These observations delineate the potential complexity of the organization of epithelial cell-matrix interactions involved in the maintenance of the human intestinal crypt-villus axis.
肠上皮是一种高度动态的组织，其快速更新和消化功能的表达依赖于多种因素的调节。在过去十年中，越来越明显的是，这些因素包括细胞通过一系列特定的细胞膜受体与细胞外基质，更具体地说是与下方的基底膜的相互作用，其中许多受体是整合素。整合素调节黏附连接的组装以及各种信号通路的激活，从而导致基因表达的调节。对人类小肠上皮隐窝-绒毛轴上整合素库的分析确定了一些β1和β4整合素，相对于其两个功能区室，它们表现出不同的表达模式。其中包括整合素α3β1、α7Bβ1和α6β4的功能形式，它们似乎与其配体的分布一起，与肠细胞分化过程相关；还有整合素α2β1、α1β1、α5β1以及α6β4的非功能形式，它们似乎与隐窝细胞的未分化/增殖状态相关。这些观察结果描绘了参与维持人类肠隐窝-绒毛轴的上皮细胞-基质相互作用组织的潜在复杂性。
