Harding K G, Jones V, Price P
Wound Healing Research Unit, University of Wales College of Medicine, Cardiff, UK.
Diabetes Metab Res Rev. 2000 Sep-Oct;16 Suppl 1:S47-50. doi: 10.1002/1520-7560(200009/10)16:1+<::aid-dmrr133>3.0.co;2-q.
Wounds have existed since the beginning of time. The interest in this subject has been stimulated in the main by conflict and war that have necessitated the development of new ways of managing wounds. In the 1960s the development of new materials that maintained a moist environment in the wound area encouraged a number of commercial companies to produce a wide variety of new materials with physical and chemical properties that might provide a moist environment. However the data to support the use of such materials are limited if one requires evidence that they have produced more rapid healing in chronic wounds kept moist as to those kept dry. Is this due to a problem with the outcome measure rather than a problem with the materials themselves? Rather than seeing this as justification for not using such materials, it should instead lead clinicians to question the validity of endpoint studies in wound healing experiments. There is a lack of evidence regarding the ability of such materials to improve the speed of healing in chronic wounds. Nevertheless considerable clinical experience, obtained from treating many patients, has indicated that not only are such new treatments cost effective, but that they are also proving to be extremely beneficial and acceptable to patients, on account of their ability to reduce pain, odour or leakage from a wound.
