Cao W B, Gao C Y
Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Zhonghua Shao Shang Za Zhi. 2021 Nov 20;37(11):1090-1098. doi: 10.3760/cma.j.cn501120-20210715-00249.
Diabetes can lead to a variety of complications, such as chronic wound (diabetic foot), which is one of the important causes of death for patients with diabetes. Unfavorable factors such as high blood glucose, high level of oxidative stress and inflammation, and susceptibility to infection lead to difficult healing and even worsening of diabetic chronic wounds. Due to the advantages of high water content, good biocompatibility, and tunable physicochemical properties, the hydrogels have become hot-spot materials in wound dressing research. Compared with the traditional dressings such as gauze, the hydrogel dressings can provide a moist environment that is beneficial for wound healing. By loading of bioactive components and modulation of compositions and structures of hydrogels, the hydrogel dressings can be endowed with excellent tissue adhesion, antibacterial ability, anti-oxidation, and inflammation regulation effect, etc., and thus show great prospects in wound dressing applications. Based on the characteristics of hydrogel materials and microenvironment of diabetic chronic wound, this review summarized the research advances on new multifunctional hydrogel dressings for the treatment of diabetic chronic wounds in recent years, and discussed the drawbacks of current hydrogel dressings with prospects proposed.
糖尿病会引发多种并发症，如慢性伤口（糖尿病足），这是糖尿病患者的重要死亡原因之一。高血糖、高氧化应激和炎症水平以及易感染等不利因素导致糖尿病慢性伤口愈合困难甚至恶化。由于水含量高、生物相容性好以及理化性质可调等优点，水凝胶已成为伤口敷料研究中的热点材料。与纱布等传统敷料相比，水凝胶敷料能提供有利于伤口愈合的湿润环境。通过负载生物活性成分以及调节水凝胶的组成和结构，水凝胶敷料可具备优异的组织黏附性、抗菌能力、抗氧化和炎症调节作用等，从而在伤口敷料应用中展现出广阔前景。基于水凝胶材料的特性和糖尿病慢性伤口的微环境，本综述总结了近年来用于治疗糖尿病慢性伤口的新型多功能水凝胶敷料的研究进展，并讨论了当前水凝胶敷料的缺点及提出的前景。
