MMWR Morb Mortal Wkly Rep. 2000 Oct 6;49(39):885-8.
Patients with Rocky Mountain spotted fever (RMSF), a tickborne infection caused by Rickettsia rickettsii, respond quickly to tetracycline-class antibiotics (e.g., doxycycline) when therapy is started within the first few days of illness; however, untreated RMSF may result in severe illness and death. Persons aged <10 years have the highest age-specific incidence of RMSF. This report summarizes the clinical course and outcome of RMSF in four children from four regions of the United States and underscores the need for clinicians throughout the United States to consider RMSF in children with rash and fever, particularly those with a history of tick bite or who present during April-September when approximately 90% of RMSF cases occur.
落基山斑疹热（RMSF）是一种由立氏立克次体引起的蜱传播感染，在发病头几天内开始治疗时，患者对四环素类抗生素（如多西环素）反应迅速；然而，未经治疗的RMSF可能导致严重疾病和死亡。10岁以下人群的RMSF年龄别发病率最高。本报告总结了来自美国四个地区的四名儿童的RMSF临床病程和结局，并强调美国各地的临床医生有必要考虑对有皮疹和发热的儿童进行RMSF评估，特别是那些有蜱叮咬史或在4月至9月发病的儿童，这期间约90%的RMSF病例会出现。
