Narita M, Uchimura A, Kimura K, Tanimura N, Yanai T, Masegi T, Fukushi H, Hirai K
National Institute of Animal Health, Ministry of Agriculture, Forestry, and Fisheries, Tsukuba, Ibaraki, Japan.
Vet Pathol. 2000 Sep;37(5):476-9. doi: 10.1354/vp.37-5-476.
We demonstrated that pigs are susceptible to acute infection by equine herpesvirus type 9 (EHV-9). Six 8-week-old SPF pigs were inoculated intranasally and four were inoculated orally with different doses of EHV-9, and observed for 6 days. Although neurological signs did not develop in any of the infected pigs, the six intranasally infected pigs and one of the orally infected pigs developed lesions of encephalitis consisting of neuronal necrosis, neuronophagia, and intranuclear inclusion bodies, distributed mainly in the rhinencephalon. EHV-9 antigen was localized in the necrotic neuronal cells and was closely associated with the presence of inclusion bodies. These findings clearly demonstrate that pigs are fully susceptible to EHV-9 infection following intranasal inoculation (but less so following oral inoculation), and that EHV-9 in pigs has a highly neurotropic nature.
我们证明猪对9型马疱疹病毒（EHV-9）的急性感染易感。6只8周龄的无特定病原体（SPF）猪经鼻内接种，4只经口接种不同剂量的EHV-9，并观察6天。尽管所有感染猪均未出现神经症状，但6只经鼻内感染的猪和1只经口感染的猪出现了脑炎病变，包括神经元坏死、噬神经细胞现象和核内包涵体，主要分布在嗅脑。EHV-9抗原定位于坏死的神经细胞中，并与包涵体的存在密切相关。这些发现清楚地表明，猪经鼻内接种后对EHV-9感染完全易感（经口接种时易感性较低），并且猪体内的EHV-9具有高度嗜神经性。
