Sonn J, Mayevsky A
Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel.
Brain Res. 2000 Nov 3;882(1-2):212-6. doi: 10.1016/s0006-8993(00)02827-4.
The effect of cortical spreading depression (CSD) on oxygen demand (extracellular K(+)), oxygen supply (cerebral blood flow - CBF) and oxygen balance (mitochondrial NADH) was studied by a special multiprobe assembly (MPA), during hypoxia and partial ischemia. The MPA was constructed and applied to monitor the CSD wave from its front line until complete recovery, continuously and simultaneously. CSD under hypoxia or partial ischemia led to an initial increase in NADH levels and a further decrease in CBF during the first phase of the CSD wave, indicating a decrease of tissue capability to compensate for an increase in oxygen demand. Furthermore, the special design of the MPA enabled identifying the close interrelation between oxygen demand, supply and balance during CSD propagation. In conclusion, brain oxygenation was shown to have a clear effect on tissue responses to CSD.
采用一种特殊的多探头装置（MPA），研究了缺氧和局部缺血期间皮质扩散性抑制（CSD）对氧需求（细胞外K(+)）、氧供应（脑血流量 - CBF）和氧平衡（线粒体NADH）的影响。构建并应用MPA从CSD波的前沿连续、同步地监测其直至完全恢复。缺氧或局部缺血条件下的CSD在CSD波的第一阶段导致NADH水平最初升高，随后CBF进一步降低，表明组织补偿氧需求增加的能力下降。此外，MPA的特殊设计能够识别CSD传播过程中氧需求、供应和平衡之间的密切相互关系。总之，脑氧合对组织对CSD的反应有明显影响。
