Wramsby M L, Sten-Linder M, Bremme K
Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden.
Fertil Steril. 2000 Nov;74(5):987-91. doi: 10.1016/s0015-0282(00)01545-4.
To analyze the prevalence of the mutation G1691A in factor V gene (Leiden mutation), of mutation C677T in the methylenetetrahydrofolate reductase (MTHFR) gene, and of polymorphism in G20210A in the prothrombin gene in women with recurrent abortions; further, to identify a subgroup at higher risk of being carriers of these mutations.
Prospective case control evaluation.
University clinic.
PATIENT(S): Eighty-four women with 3 or more consecutive miscarriages were compared with 69 controls.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Polymerase chain reactions were performed to identify the mutations G1691A in factor V and C677T in MTHFR genes and the polymorphism G20210A in the prothrombin gene.
RESULT(S): In women with primary habitual abortions, 27.8% carried the Leiden mutation. No difference was observed in the prevalence of mutation C677T in the MTHFR gene or in polymorphism G20210A in the prothrombin gene.
CONCLUSION(S): The Leiden mutation may play a considerable role for women having primary recurrent abortions.
