在狒狒模型中评估(99m)Tc-双胍作为肾脏成像示踪剂的情况。
Evaluation in the baboon model of (99m)Tc-biguanide as a tracer for renal imaging.
作者信息
Neves M, Dormehl I, Kilian E, Louw W, Lalaoui K, Pedroso de Lima J J
机构信息
Instituto Tecnológico e Nuclear, Sacavém, Portugal.
出版信息
Nucl Med Biol. 2000 Aug;27(6):593-7. doi: 10.1016/s0969-8051(00)00128-1.
Studies in various animal species have recently shown that (99m)Tc-BIG has practical and dosimetric benefits for renal imaging that could probably make it a good alternative to (99m)Tc-2, 3-dimercaptosuccinic acid ((99m)Tc-DMSA). In this study, using the baboon experimental model, the biodistribution of (99m)Tc-BIG and (99m)Tc-DMSA are compared. It is demonstrated that early good contrast imaging and more favourable dosimetry is possible with (99m)Tc-BIG compared to (99m)Tc-DMSA, confirming the quoted previous findings with small animals. Time-activity curves for kidneys and other organs support these findings, and MIRDOSE software provided the dosimetry.
最近在各种动物物种上进行的研究表明，（99m）Tc - BIG在肾脏成像方面具有实际应用价值和剂量学优势，这可能使其成为（99m）Tc - 2,3 - 二巯基丁二酸（（99m）Tc - DMSA）的良好替代品。在本研究中，使用狒狒实验模型，比较了（99m）Tc - BIG和（99m）Tc - DMSA的生物分布。结果表明，与（99m）Tc - DMSA相比，（99m）Tc - BIG能够实现早期良好的对比成像，且剂量学更有利，这证实了之前在小动物上引用的研究结果。肾脏和其他器官的时间 - 活性曲线支持了这些发现，并且MIRDOSE软件提供了剂量学数据。
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