Nakayama J
Department of Dermatology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.
Eur J Dermatol. 2000 Oct-Nov;10(7):528-32.
A 71-year-old woman visited our clinic due to the presence of widespread scaly erythema on her face, scalp, and lower extremities. She was tentatively diagnosed as having seborrheic dermatitis but the symptoms were difficult to distinguish from psoriasis vulgaris. As a result, she was diagnosed as having sebopsoriasis. She was treated topically with an active vitamin D3 compound, 1a-24 (R)-dihydroxycholecalciferol D3 (tacalcitol) cream. She applied tacalcitol cream twice daily for 4 weeks, and her facial eruptions thus cleared up completely. No recurrence was observed for 2 months thereafter, even though the use of tacalcitol cream was stopped. To investigate whether or not tacalcitol cream is generally effective for the treatment of such seborrheic dermatitis-like eruptions, three more patients were treated with tacalcitol cream. All patients exhibited scaly erythematous macules on the face and/or scalp, and their eruptions improved rapidly with tacalcitol cream. Tacalcitol cream was thus found to be effective and useful for the treatment of both sebopsoriasis and even seborrheic dermatitis of the face and scalp.
一名71岁女性因面部、头皮和下肢出现广泛的鳞屑性红斑前来我院就诊。她初步被诊断为脂溢性皮炎，但症状难以与寻常型银屑病区分。因此，她被诊断为脂溢性银屑病。她接受了活性维生素D3化合物1α-24（R）-二羟基胆钙化醇D3（他卡西醇）乳膏的局部治疗。她每天两次涂抹他卡西醇乳膏，持续4周，面部皮疹因此完全消退。此后2个月未观察到复发，即使停止使用他卡西醇乳膏。为了研究他卡西醇乳膏对治疗此类脂溢性皮炎样皮疹是否普遍有效，另外三名患者接受了他卡西醇乳膏治疗。所有患者面部和/或头皮均出现鳞屑性红斑丘疹，使用他卡西醇乳膏后皮疹迅速改善。因此发现他卡西醇乳膏对治疗脂溢性银屑病以及面部和头皮的脂溢性皮炎均有效且有用。
