Cherek D R, Lane S D
Department of Psychiatry and Behavioral Sciences, University of Texas-Houston Health Science Center 77030-3497, USA.
Psychopharmacology (Berl). 2000 Oct;152(2):149-56. doi: 10.1007/s002130000530.
The role of serotonin in impulsivity was examined by administering the serotonin-releasing drug, d,l-fenfluramine, and measuring effects on impulsive responding of male subjects with and without a history of conduct disorder (CD) under controlled laboratory conditions.
Five adult male subjects with a history of CD and five matched controls were recruited into a study to determine the acute effects of d,l-fenfluramine on a laboratory measure of impulsive behavior. This laboratory measure, based upon delay of gratification, presented subjects with choices between a small reward after a short delay and a larger reward after a longer delay. Impulsive behavior was indicated by frequent choices for the smaller reward.
Acute oral doses of d,l-fenfluramine (0.21, 0.42, and 0.85 mg/kg) produced decreases in the number of impulsive choices in all subjects with a history of CD, but had no effect on the control subjects.
This data suggests that a deficit in serotonin and/or dopamine may play a role in impulsivity in CD subjects, and drugs which act to reduce this biological deficit can reduce impulsiveness.
通过给予释放血清素的药物d，l - 芬氟拉明，并在受控实验室条件下测量其对有和没有品行障碍（CD）病史的男性受试者冲动反应的影响，来研究血清素在冲动性中的作用。
招募了五名有CD病史的成年男性受试者和五名匹配的对照组，以确定d，l - 芬氟拉明对实验室冲动行为测量的急性影响。这种基于延迟满足的实验室测量方法，让受试者在短延迟后的小奖励和长延迟后的大奖励之间做出选择。频繁选择较小奖励表明存在冲动行为。
急性口服剂量的d，l - 芬氟拉明（0.21、0.42和0.85毫克/千克）使所有有CD病史的受试者的冲动选择次数减少，但对对照组受试者没有影响。
该数据表明血清素和/或多巴胺缺乏可能在CD受试者的冲动性中起作用，而作用于减少这种生物学缺陷的药物可以降低冲动性。
