New Antonia S, Trestman Robert F, Mitropoulou Vivian, Goodman Marianne, Koenigsberg Harold H, Silverman Jeremy, Siever Larry J
Psychiatry Service-116 A, Bronx VA Medical Center, Bronx, NY 10468, USA.
J Psychiatr Res. 2004 May-Jun;38(3):223-30. doi: 10.1016/j.jpsychires.2003.09.001.
To examine the prolactin (prl) response to d,l-fenfluramine in a large sample of personality disorder patients with impulsive aggression. Patients were screened from clinics at the Bronx VAMC and the Mount Sinai Medical Center and from press releases. One hundred and forty-six personality disorder patients (90M;56F) and 23 normal controls (15M;8F) underwent oral d,l-fenfluramine challenge. The peak change in prolactin(deltapkprl) was calculated by subtracting baseline prolactin from peak response following fenfluramine administration (3 h). Analysis of variance and regression analysis were used to detect group differences in deltapkprl. Deltapkprl in impulsive aggressive men, but not women, with personality disorders was blunted compared with controls. Men with suicide histories also had a blunted deltapkprl compared with those without, which was not accounted for by depression. This study represents a replication of previous studies, in a much larger sample, showing a blunted PRL response to fenfluramine of male patients with personality disorder in relation to impulsive aggression and to suicide attempts.
为了在大量患有冲动攻击性的人格障碍患者样本中研究催乳素（PRL）对d，l-芬氟拉明的反应。从布朗克斯退伍军人医疗中心和西奈山医疗中心的诊所以及新闻稿中筛选患者。146名人格障碍患者（90名男性；56名女性）和23名正常对照者（15名男性；8名女性）接受了口服d，l-芬氟拉明激发试验。催乳素的峰值变化（deltapkprl）通过在给予芬氟拉明后3小时的峰值反应中减去基线催乳素来计算。采用方差分析和回归分析来检测deltapkprl的组间差异。与对照组相比，患有冲动攻击性人格障碍的男性（而非女性）的deltapkprl减弱。有自杀史的男性与无自杀史的男性相比，其deltapkprl也减弱，且这并非由抑郁所致。本研究在更大的样本中重复了先前的研究，表明患有冲动攻击性和有自杀企图的男性人格障碍患者对芬氟拉明的PRL反应减弱。
