Coccurello R, Adriani W, Oliverio A, Mele A
Dipartimento di Genetica e Biologia Molecolare, Università di Roma La Sapienza, Rome, Italy.
Psychopharmacology (Berl). 2000 Oct;152(2):189-99. doi: 10.1007/s002130000515.
Some evidence suggests an involvement of nucleus accumbens in spatial learning. However, it is controversial whether the mesoaccumbens dopaminergic pathways play a specific role in the acquisition of spatial information.
The goal of these experiments was to investigate the effect of dopaminergic manipulations in the nucleus accumbens on a non-associative task designed to estimate the ability to encode/transmit spatial and non-spatial information.
The effects of focal administrations of the D1 and D2 dopamine receptor antagonists, SCH 23390 (6.25, 12.5, 50 ng/side) and sulpiride (12.5, 50, 100 ng/side), respectively, and dopamine (DA; 1.25 and 2.5 microg/side) into the nucleus accumbens were studied on reactivity to spatial and non-spatial changes in an open field with objects.
Both SCH 23390 and sulpiride impaired reactivity to spatial change. However, several differences were found in the effects induced by the two DA antagonists. SCH 23390 did not affect locomotor activity and only slightly impaired exploration of the novel object. On the contrary, the D2 antagonist, induced a general, dose-dependent, impairment on all variables measured. Local administration of DA increased locomotor activity, but did not affect reactivity to spatial and non-spatial changes.
These results demonstrate a facilitatory role of mesoaccumbens dopamine in the acquisition of spatial information. Moreover, they suggest that nucleus accumbens D1 DA receptors, play a more selective role in the modulation of spatial learning than accumbens D2 DA receptors.
一些证据表明伏隔核参与空间学习。然而，中脑伏隔核多巴胺能通路在空间信息获取中是否发挥特定作用仍存在争议。
这些实验的目的是研究伏隔核中多巴胺能操作对一项旨在评估编码/传递空间和非空间信息能力的非联想任务的影响。
分别向伏隔核局部注射D1和D2多巴胺受体拮抗剂SCH 23390（6.25、12.5、50纳克/侧）和舒必利（12.5、50、100纳克/侧）以及多巴胺（DA；1.25和2.5微克/侧），研究其对有物体的开放场中空间和非空间变化的反应性。
SCH 23390和舒必利均损害对空间变化的反应性。然而，发现两种多巴胺拮抗剂诱导的效应存在一些差异。SCH 23390不影响运动活动，仅轻微损害对新物体的探索。相反，D2拮抗剂对所有测量变量均产生普遍的、剂量依赖性的损害。局部注射多巴胺增加运动活动，但不影响对空间和非空间变化的反应性。
这些结果证明中脑伏隔核多巴胺在空间信息获取中起促进作用。此外，它们表明伏隔核D1多巴胺受体在空间学习调节中比伏隔核D2多巴胺受体发挥更具选择性的作用。
