前列腺疾病中表皮生长因子受体（EGFR）基因扩增及多态性的观察
Observations on EGFR gene amplification and polymorphism in prostatic diseases.
作者信息
Kumar V L, Majumder P K, Kumar V
机构信息
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
出版信息
Int Urol Nephrol. 2000;32(1):73-5. doi: 10.1023/a:1007160202229.
This study was designed to determine the amplification and polymorphism of epidermal growth factor receptor (EGFR) gene in prostatic diseases like benign hypertrophy (BPH) and carcinoma (CaP). The EGFR gene was found to be amplified in grade IV BPH as compared to grade II BPH. Digestion of genomic DNA with MspI and HpaII revealed the presence of a 5kb band following southern blot analysis. This 5kb band was present in all the CaP cases and in one out of three BPH cases. It is possible that such a polymorphism is associated with the type or extent of tumor progression.
本研究旨在确定表皮生长因子受体（EGFR）基因在良性前列腺增生（BPH）和前列腺癌（CaP）等前列腺疾病中的扩增及多态性。与II级BPH相比，IV级BPH中发现EGFR基因存在扩增。用MspI和HpaII消化基因组DNA后，Southern印迹分析显示存在一条5kb的条带。这条5kb的条带在所有CaP病例以及三分之一的BPH病例中出现。这种多态性有可能与肿瘤进展的类型或程度相关。
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