Farmer R G
Surg Clin North Am. 1975 Dec;55(6):1335-41. doi: 10.1016/s0039-6109(16)40790-5.
The efficacy of the neomycin-erythromycin combination as prophylaxis before operation for carcinoma of the colon (3 gm. of each of the day preoperatively, plus mechanical cleansing) was evaluated in a study of 74 patients for whom primary operations for colon carcinoma were performed from January 1973 through June 1974. Twenty three other patients received other preparations. Of the 74 who received neomycin and erythromycin, 4 had postoperative infectious complications (5 per cent). Of the 23 patients who received other preparations, 8 had significant complications (35 per cent). Although operability, age, concurrent medical problems and surgical technique probably influence postoperative sepsis, the use of oral neomycin-erythromycin combination as preoperative prophylaxis appears satisfactory for prevention of infection after operations for colon carcinoma.
1973年1月至1974年6月期间，对74例接受结肠癌一期手术的患者进行了一项研究，评估了新霉素 - 红霉素联合用药（术前每日各3克，外加机械清洁）作为结肠癌手术前预防用药的疗效。另外23例患者接受了其他制剂。在接受新霉素和红霉素的74例患者中，4例出现术后感染并发症（5%）。在接受其他制剂的23例患者中，8例出现严重并发症（35%）。虽然手术可操作性、年龄、并存的内科问题和手术技术可能影响术后败血症，但口服新霉素 - 红霉素联合用药作为术前预防用药，对于预防结肠癌手术后的感染似乎是令人满意的。
