Kallen K J, Grötzinger J, Rose-John S
Institut für Biochemie, Christian-Albrechts Universität zu Kiel, D-24098, Kiel, Germany.
Trends Biotechnol. 2000 Nov;18(11):455-61. doi: 10.1016/s0167-7799(00)01492-x.
A combination of molecular modelling, conventional epitope scanning and combinatorial techniques, such as phage display and DNA shuffling, has greatly improved our understanding of ligand-receptor interactions. It has therefore been possible to develop powerful cytokine-growth factor antagonists and new designer cytokines, with altered receptor specificities or with greatly enhanced biological activity. Recently, small circular peptides that mimic or block the effects of natural cytokines and growth factors have been developed; such small peptides are likely to open new avenues in therapeutics.
分子建模、传统表位扫描以及噬菌体展示和DNA改组等组合技术相结合，极大地增进了我们对配体-受体相互作用的理解。因此，已经有可能开发出强大的细胞因子-生长因子拮抗剂和新型设计细胞因子，它们具有改变的受体特异性或大大增强的生物活性。最近，已经开发出了模拟或阻断天然细胞因子和生长因子作用的小环肽；这类小肽很可能会为治疗开辟新途径。
