gp130细胞因子的受体识别
Receptor recognition by gp130 cytokines.
作者信息
Bravo J, Heath J K
机构信息
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
出版信息
EMBO J. 2000 Jun 1;19(11):2399-411. doi: 10.1093/emboj/19.11.2399.
Abstract
Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry. Analysis of the three-dimensional structure of selected ligands and receptor elements indicates that ligands display three topologically conserved receptor recognition epitopes that interact with complementary ligand recognition elements. The composition of the signalling complex and downstream biological responses is defined by the relative affinity of different receptor components for these epitopes. The detailed structure of receptor recognition epitopes indicates that the generation of small molecule cytokine mimetics may be a feasible objective.
摘要
gp130家族的细胞因子通过形成稳定的高亲和力跨膜受体复合物发挥其多样的生物学效应，这些复合物的特征是存在共享的跨膜信号受体gp130。不同的gp130配体形成在组成和化学计量上都不同的信号复合物。对选定配体和受体元件的三维结构分析表明，配体显示出三个拓扑保守的受体识别表位，它们与互补的配体识别元件相互作用。信号复合物的组成和下游生物学反应由不同受体组分对这些表位的相对亲和力决定。受体识别表位的详细结构表明，生成小分子细胞因子模拟物可能是一个可行的目标。
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