Adikwu M U, Attama A A
Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Boll Chim Farm. 2000 Jul-Aug;139(4):173-6.
Prosopis africana gum was evaluated for use in the formulation of gels. The rate of release of salicylic acid from gels prepared from prosoopis gum was investigated. The rate of permeation of the drug through the gel was also evaluated. Surfactants were incorporated into the gels and the effect on the release and permeation was also investigated. Tragacanth gum gel was also prepared and used as the standard. The release and permeation of the drug from the gel was low. Incorporation of surfactants did not enhance the release of the drug. However the low release and permeation rates may be due to the poor water solubility of the incorporated drug. Correlation of the quantity of drug released with viscosity shows that drug release was dependent on the viscosity of the gels; the highly viscous gels showed slower release rates.
对非洲牧豆树胶在凝胶制剂中的应用进行了评估。研究了从牧豆树胶制备的凝胶中水杨酸的释放速率。还评估了药物通过凝胶的渗透速率。将表面活性剂加入凝胶中，并研究其对释放和渗透的影响。还制备了刺梧桐树胶凝胶并用作标准品。药物从凝胶中的释放和渗透较低。加入表面活性剂并未提高药物的释放。然而，低释放和渗透速率可能是由于所加入药物的水溶性差。药物释放量与粘度的相关性表明，药物释放取决于凝胶的粘度；高粘度凝胶的释放速率较慢。
