使用生物阻抗测量的冷冻手术监测——电阻抗断层成像的可行性研究
Cryosurgical monitoring using bioimpedance measurements--a feasibility study for electrical impedance tomography.
作者信息
Otten D M, Rubinsky B
机构信息
Department of Mechanical Engineering, University of California at Berkeley 94720, USA.
出版信息
IEEE Trans Biomed Eng. 2000 Oct;47(10):1376-81. doi: 10.1109/10.871411.
The effectiveness of cryosurgery in treating tumors is highly dependent on knowledge of freezing extent, and therefore relies heavily on real-time imaging techniques for monitoring. Electrical impedance tomography (EIT), which utilizes tissue impedance variation to construct an image, is very well suited to cryosurgery since frozen tissue impedance is much higher than that of unfrozen tissue. In this study, we explore cryosurgical monitoring as a previously uninvestigated application for EIT. The feasibility of bio-impedance measurements to detect ice front propagation is demonstrated by freezing planar tissue samples one-dimensionally while measuring impedance along a linear array. The experimental results compare favorably to a simple finite element model designed to provide an electrical field visualization tool.
冷冻手术治疗肿瘤的有效性高度依赖于对冷冻范围的了解，因此严重依赖实时成像技术进行监测。电阻抗断层成像（EIT）利用组织阻抗变化来构建图像，非常适合冷冻手术，因为冷冻组织的阻抗远高于未冷冻组织。在本研究中，我们探索将冷冻手术监测作为EIT以前未被研究的应用。通过一维冷冻平面组织样本同时沿线性阵列测量阻抗，证明了生物阻抗测量检测冰前沿传播的可行性。实验结果与设计用于提供电场可视化工具的简单有限元模型相比具有优势。
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