Zhang Z Q, Su Z G
State Key Laboratory of Biochemical Engineering, Chinese Academy of Sciences, Beijing.
Sheng Wu Gong Cheng Xue Bao. 2000 May;16(3):378-82.
Under the catalysis of Al2O3, 7-epi-taxol in Taxus yunnanensis extract could convert to taxol. The factors including the concentration of CH3OH in the mobile phase, the type of Al2O3 and the reaction time could influence the isomeric reaction. The catalysis mechanism fo Al2O3 was investigated. The isomerization of 7-epi-taxol was under the cooperation of the Lewis souci activity core and the basic activity core in the surface of Al2O3 at room temperature. The type and strength of activity core controlled the procedure of reaction, and the suitable content of CH3OH in the mobile phase would accelerate the reaction.
在Al2O3的催化作用下，云南红豆杉提取物中的7-表紫杉醇可转化为紫杉醇。流动相中甲醇浓度、Al2O3类型和反应时间等因素会影响异构化反应。对Al2O3的催化机理进行了研究。7-表紫杉醇的异构化是在室温下Al2O3表面的路易斯酸活性中心和碱性活性中心共同作用下进行的。活性中心的类型和强度控制着反应进程，流动相中合适的甲醇含量会加速反应。
