Rhee Y K, Bae E A, Kim S Y, Han M J, Choi E C, Kim D H
Department of Food and Nutrition, Kyung Hee University, Seoul, Korea.
Arch Pharm Res. 2000 Oct;23(5):482-7. doi: 10.1007/BF02976577.
The antitumor activity of Bifidobacterium breve K-110, and K-111, and B. infantis K-525 was investigated. These Bifidobacterial cells and their cell wall preparations (WPG) significantly increased the survival rate of mice who had been intraperitoneally implanted with sarcoma 180 cells. Solid tumor growth was inhibited even when the sarcoma 180 cells were implanted into the groins of the mice. However, the Bifidobacterial cells did not show in vitro cytotoxicity against tumor cell lines. Cell kinetic studies revealed that these WPGs induced neutrophils, which were followed by macrophages, at the site of peritoneal injection. The WPGs directly activated these cells to inhibit the growth of tumor cells in in vitro assays. Our results suggest that Bifidobacterial WPGs induce and activate nonspecific phagocytes in situ to reject growing tumor cells in the mouse peritoneal cavity.
研究了短双歧杆菌K-110、K-111以及婴儿双歧杆菌K-525的抗肿瘤活性。这些双歧杆菌细胞及其细胞壁制剂（WPG）显著提高了腹腔注射肉瘤180细胞的小鼠的存活率。即使将肉瘤180细胞植入小鼠腹股沟，实体瘤生长也受到抑制。然而，双歧杆菌细胞对肿瘤细胞系未表现出体外细胞毒性。细胞动力学研究表明，这些WPG在腹腔注射部位诱导了中性粒细胞，随后是巨噬细胞。在体外试验中，WPG直接激活这些细胞以抑制肿瘤细胞生长。我们的结果表明，双歧杆菌WPG在原位诱导并激活非特异性吞噬细胞，以排斥小鼠腹腔内生长的肿瘤细胞。
