Knoll T, Schaub M, Birck R, Braun C, Juenemann K P, Rohmeiss P
Department of Urology, University Hospital Mannheim, University of Heidelberg, Germany Faculty of Clinical Medicine of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68135 Mannheim, Germany.
Expert Opin Investig Drugs. 2000 May;9(5):1041-52. doi: 10.1517/13543784.9.5.1041.
The endothelin system has been identified as having a substantial role in renal failure, both acute and chronic. Beside its well characterised haemodynamic effects, its mitogenic and pro-fibrotic properties have gained increased interest in the pathophysiology of chronic renal failure. This review outlines the role of endothelin in the pathogenesis of various renal diseases with a special focus on the potential of blocking this system with endothelin receptor antagonists. So far, most data were derived from animal models, but they provide strong evidence that endothelin receptor antagonists may represent a powerful therapeutic strategy in ameliorating the course of acute and chronic renal failure.
内皮素系统已被证实，在急慢性肾衰竭中发挥着重要作用。除了其已被充分认识的血流动力学效应外，其促有丝分裂和促纤维化特性在慢性肾衰竭的病理生理学中也引起了越来越多的关注。这篇综述概述了内皮素在各种肾脏疾病发病机制中的作用，特别关注使用内皮素受体拮抗剂阻断该系统的潜力。到目前为止，大多数数据来自动物模型，但它们提供了强有力的证据，表明内皮素受体拮抗剂可能是改善急慢性肾衰竭病程的一种有效治疗策略。
