Benigni A
Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
Curr Opin Nephrol Hypertens. 1995 Jul;4(4):349-53. doi: 10.1097/00041552-199507000-00011.
The sensitivity of the renal vasculature to endothelin-1 together with the effect of the peptide on the kidney prompted investigators to study the role of endothelin-1 in renal pathophysiology. The kidney expresses both endothelinA and endothelinB receptors, which differ from species to species. Experiments employing specific endothelin receptor antagonists in experimental animals have suggested a role for endothelin-1 in ischaemia-induced acute renal failure and renal disease progression.
肾血管系统对内皮素 -1 的敏感性以及该肽对肾脏的作用促使研究人员去研究内皮素 -1 在肾脏病理生理学中的作用。肾脏表达内皮素 A 受体和内皮素 B 受体，不同物种的这两种受体存在差异。在实验动物中使用特异性内皮素受体拮抗剂的实验表明，内皮素 -1 在缺血性急性肾衰竭和肾脏疾病进展中发挥作用。
