Akçakaya N, Hassanzadeh A, Camcioğlu Y, Cokuğraş H
Department of Pediatrics, Cerrahpaşa Medical Faculty, University of Istanbul, Turkey.
Ann Allergy Asthma Immunol. 2000 Oct;85(4):317-21. doi: 10.1016/S1081-1206(10)62536-7.
We retrospectively evaluated the incidence of local and systemic reactions to injections of adsorbed extracts of house dust mites (Dermatophagoides pteronyssinus and Dermatophagoides farinae) applied according to a conventional schedule in children.
Eighty-eight patients aged 6 to 15 years, suffering from allergic asthma or asthma together with rhinitis, at various stages of treatment with immunotherapy from January 1989 to November 1997 were included.
Out of 5,760 injections, 5,542 (96.21%) were not associated with a reaction, 206 injections (3.57%) caused local reactions (144, <20 mm in diameter; 62, >20 mm), and systemic reactions were seen after 12 injections (0.2%). Twelve patients experienced 12 systemic reactions. Of these, 7 patients (58.3%) experienced no local reactions prior to a systemic reaction. Eleven males and one female had systemic reactions. Most of both local and systemic reactions occurred within less than 30 minutes after the injection.
Our study supports the safety of immunotherapy with house dust mites in children. The majority of reactions were local. Although five of 12 patients who experienced systemic reactions had local reactions prior to a systemic reaction, in general the presence of local reactions was not helpful in predicting which patients would develop systemic reactions. Males and patients with asthma together with rhinitis appeared to be at greater risk for systemic reactions.
我们回顾性评估了按照常规方案给儿童注射粉尘螨（屋尘螨和粉尘螨）吸附提取物后局部和全身反应的发生率。
纳入了1989年1月至1997年11月期间处于免疫治疗不同阶段、年龄在6至15岁、患有过敏性哮喘或哮喘合并鼻炎的88例患者。
在5760次注射中，5542次（96.21%）未出现反应，206次注射（3.57%）引起局部反应（144次，直径<20毫米；62次，直径>20毫米），12次注射后出现全身反应（0.2%）。12名患者出现了12次全身反应。其中，7名患者（58.3%）在出现全身反应之前未出现局部反应。11名男性和1名女性出现了全身反应。大多数局部和全身反应发生在注射后不到30分钟内。
我们的研究支持儿童粉尘螨免疫治疗的安全性。大多数反应为局部反应。虽然12名出现全身反应的患者中有5名在出现全身反应之前有局部反应，但总体而言，局部反应的出现无助于预测哪些患者会发生全身反应。男性以及患有哮喘合并鼻炎的患者似乎发生全身反应的风险更高。
