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豚鼠下丘脑大细胞神经分泌系统。II. 胎儿中神经垂体素和加压素的免疫组织化学定位

The hypothalamic magnocellular neurosecretory system of the guinea pig. II. Immunohistochemical localization of neurophysin and vasopressin in the fetus.

作者信息

Silverman A J

出版信息

Am J Anat. 1975 Dec;144(4):445-59. doi: 10.1002/aja.1001440405.

DOI:10.1002/aja.1001440405
PMID:1106175
Abstract

The development of the hypothalamic magnocellular neurosecretory system of the fetal guinea pig was examined by immunohistochemistry. Neurophysin was first observed in the supraoptic nucleus (SON), median eminence (ME) and posterior pituitary (PP) on day 40 of gestation. It was not regularly present in the paraventricular nucleus (PVN) until day 47. Vasopressin was first observed in the SON, ME and PP on day 45. In the median eminence immunoreactive deposits indicative of both peptides were observed in both the fibers of the hypothalamo-hypophysial tract (H-HT) in the presumptive zona interna as well as in axons projecting to the developing primary portal plexus.

摘要

通过免疫组织化学方法研究了豚鼠胎儿下丘脑大细胞神经分泌系统的发育。在妊娠第40天，首先在视上核（SON）、正中隆起（ME）和垂体后叶（PP）中观察到神经垂体素。直到第47天，它才在室旁核（PVN）中规律出现。血管加压素在第45天首次在视上核、正中隆起和垂体后叶中被观察到。在正中隆起中，在假定的内侧带的下丘脑 - 垂体束（H-HT）纤维以及投射到发育中的初级门静脉丛的轴突中，均观察到了指示这两种肽的免疫反应性沉积物。

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