Mulero F, Roca V, Nicolás F, Castellón I, Fuentes T, Abad L, Illana J, Nuño de la Rosa J A
Servicio de Medicina Nuclear, Hospital Universitario Virgen de la Arrixaca, Murcia.
Rev Esp Med Nucl. 2000 Jun;19(3):192-8.
Scintigraphy studies with (99m)Tc-MIBI are widely used in the diagnosis of non-invasive breast cancer and their results have been verified by many studies. However, the scintigraphic technique produces erroneous false negative and positive results. This study aims to verify how the different characteristics of the uptake of (99m)Tc-MIBI (intensity, size, morphology, etc.) can help to increase sensitivity and specificity of breast scintigraphy.
We have studied 201 patients (84 breast cancer and 117 benign lesions). All of them underwent a breast scintigraphy with (99m)Tc-MIBI and anatomopathological study. A semiquantitative analysis (by T/F indexes) and visual study were performed in the lesions that presented radiodrug uptake.
Eleven false positive results and 8 false negative results were obtained in the study of the 201 patients. The analysis of the T/F indexes did not demonstrate any significant differences between the benign and malignant lesions (p>0,05). There is a statistically significant correlation (p<0.05) between the tracer uptake morphology and the AP diagnosis and between the localization of the lesion in a breast quadrant and the uptake intensity.
Quantification of (99m)Tc-MIBI uptake by T/F indexes does not provide any conclusive data on the lesion's malignancy, however, a more detailed analysis of the characteristics of the tracer uptake would permit us to make the correct diagnosis and would reduce the false positive and negative results of this technique.
使用（99m）锝-甲氧基异丁基异腈（Tc-MIBI）的闪烁扫描研究广泛应用于非侵入性乳腺癌的诊断，其结果已得到多项研究的验证。然而，闪烁扫描技术会产生错误的假阴性和阳性结果。本研究旨在验证（99m）Tc-MIBI摄取的不同特征（强度、大小、形态等）如何有助于提高乳腺闪烁扫描的敏感性和特异性。
我们研究了201例患者（84例乳腺癌和117例良性病变）。所有患者均接受了（99m）Tc-MIBI乳腺闪烁扫描及解剖病理学研究。对呈现放射性药物摄取的病变进行了半定量分析（通过T/F指数）和视觉研究。
在对201例患者的研究中获得了11例假阳性结果和8例假阴性结果。T/F指数分析未显示良性和恶性病变之间有任何显著差异（p>0.05）。示踪剂摄取形态与病理诊断之间以及病变在乳腺象限中的定位与摄取强度之间存在统计学显著相关性（p<0.05）。
通过T/F指数对（99m）Tc-MIBI摄取进行定量分析并不能提供关于病变恶性程度的确切数据，然而，对示踪剂摄取特征进行更详细的分析将使我们能够做出正确诊断，并减少该技术的假阳性和阴性结果。
