Cutrone J A, Yospur L S, Khalkhali I, Tolmos J, Devito A, Diggles L, Vargas M P, Shitabata P, French S
Department of Radiology, Harbor-UCLA Medical Center, Torrance, California, USA.
J Nucl Med. 1998 Mar;39(3):449-53.
This study was undertaken to assess the relationship between the degree of 99mTc-MIBI uptake in breast lesions and the following histologic factors: neovascularity, desmoplastic reaction, cellular proliferation and mitochondrial density.
Forty-two patients who previously underwent MIBI breast imaging (4 false-negative, 12 false-positive, 15 true-negative, 11 true-positive) were studied. Immunohistochemical staining was performed for neovascularity (Factor VIII antigen), desmoplasia (alpha-actin antigen), mitochondrial density (mitochondrial antigen) and cellular proliferation (MIB-1 antigen). The degree of microscopic staining was correlated with region of interest measurements of MIBI uptake on scintigraphy.
There was a poor correlation between MIBI uptake and the degrees of neovascularity (r = 0.08, p > 0.05) and intracellular mitochondrial density (r = 0.04, p > 0.05) while there was a moderate correlation with cellular proliferation (r = 0.4, p < 0.05) and desmoplasia (r = 0.55, p < 0.001).
The degree of MIBI uptake in breast lesions is multifactorial, but it appears to be related more to the degree of desmoplastic activity and cellular proliferation than neovascularity and mitochondrial density.
本研究旨在评估乳腺病变中99mTc-MIBI摄取程度与以下组织学因素之间的关系：新生血管形成、促纤维增生反应、细胞增殖和线粒体密度。
对42例先前接受过MIBI乳腺成像的患者进行研究（4例假阴性、12例假阳性、15例真阴性、11例真阳性）。对新生血管形成（VIII因子抗原）、促纤维增生（α-肌动蛋白抗原）、线粒体密度（线粒体抗原）和细胞增殖（MIB-1抗原）进行免疫组织化学染色。显微镜下染色程度与闪烁扫描中MIBI摄取的感兴趣区域测量值相关。
MIBI摄取与新生血管形成程度（r = 0.08，p > 0.05）和细胞内线粒体密度（r = 0.04，p > 0.05）之间相关性较差，而与细胞增殖（r = 0.4，p < 0.05）和促纤维增生（r = 0.55，p < 0.001）之间存在中度相关性。
乳腺病变中MIBI摄取程度是多因素的，但似乎与促纤维增生活性和细胞增殖程度的关系比与新生血管形成和线粒体密度的关系更大。
