Pearlman E J, Thiemanun W, Castaneda B F
Am J Trop Med Hyg. 1975 Nov;24(6 Pt 1):901-9.
In an area of Thailand where chloroquine-resistant falciparum malaria is known to exist, a chemosuppressive field trial was undertaken to test the efficacy of the preparation diformyldapsone (DFD) combined with pyrimethamine (Py) in suppressing falciparum and vivax parasitemias. Six hundred and fifty-nine Thai villagers were randomly assigned to one of five treatment groups: DFD-Py; dapsone (DDS)-Py; DFD alone; Py alone; and placebo. Five hundred and ninety-three study subjects completed the 26-week trial. The combination DFD-Py given weekly was shown to be an effective chemosuppressive against both falciparum and vivax parasitmias, causing a more than fourfold reduction in falciparum and an approximately threefold reduction in vivax parasitemias; however, this combination was not more efficacious than DDS-Py for the chemosuppression of falciparum malaria. DFD alone was only moderately effective, while there was no difference in chemosuppression between Py alone and placebo.
在泰国已知存在对氯喹耐药的恶性疟原虫的一个地区，开展了一项化学预防现场试验，以测试双甲脒氨苯砜（DFD）与乙胺嘧啶（Py）联合制剂在抑制恶性疟原虫和间日疟原虫血症方面的疗效。659名泰国村民被随机分配到五个治疗组之一：DFD-Py；氨苯砜（DDS）-Py；单独使用DFD；单独使用Py；以及安慰剂组。593名研究对象完成了为期26周的试验。每周给予的DFD-Py联合制剂被证明对恶性疟原虫和间日疟原虫血症均有有效的化学预防作用，使恶性疟原虫血症减少四倍多，间日疟原虫血症减少约三倍；然而，对于恶性疟的化学预防，该联合制剂并不比DDS-Py更有效。单独使用DFD只有中度效果，而单独使用Py与安慰剂在化学预防方面没有差异。
