Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman I L, Grompe M
StemCells, 525 Del Rey Avenue, Suite C, Sunnyvale, California 94085, USA.
Nat Med. 2000 Nov;6(11):1229-34. doi: 10.1038/81326.
The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow cells in the FAH(-/-) mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Moreover, within bone marrow, only rigorously purified hematopoietic stem cells gave rise to donor-derived hematopoietic and hepatic regeneration. This result seems to contradict the conventional assumptions of the germ layer origins of tissues such as the liver, and raises the question of whether the cells of the hematopoietic stem cell phenotype are pluripotent hematopoietic cells that retain the ability to transdifferentiate, or whether they are more primitive multipotent cells.
肝祖细胞的特性具有重大的科学和临床意义。在此我们报告，向I型酪氨酸血症动物模型FAH(-/-)小鼠静脉注射成年骨髓细胞，可挽救该小鼠并恢复其肝脏的生化功能。此外，在骨髓中，只有经过严格纯化的造血干细胞才能产生供体来源的造血和肝脏再生。这一结果似乎与诸如肝脏等组织的胚层起源的传统假设相矛盾，并提出了具有造血干细胞表型的细胞是保留转分化能力的多能造血细胞，还是更原始的多能细胞这一问题。
