Mapletoft R J, Schmutz S M, Searcy G P
Department of Herd Medicine and Theriogenology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon.
Can Vet J. 2000 Oct;41(10):791-3.
A study was designed to determine the inheritance pattern of a blood platelet aggregation disorder in Simmental cattle utilizing embryo transfer technology. A Simmental donor cow that had previously produced a calf with the platelet aggregation disorder was superovulated and mated to a bull that had also produced affected offspring. Twenty-seven calves were produced from the 63 (42.9%) embryos transferred. This somewhat lower than expected pregnancy rate is suggestive of an increased rate of embryo loss. Twenty-three of 25 (92%) calves had normal platelet aggregation patterns and 2 failed to show any evidence of platelet aggregation. Data are suggestive that inheritance is not simple Mendelian recessive. A more likely scenario is that the defect is the result of the inheritance of at least 2 genes, which is also consistent with the sporadic incidence reported in the population at large.
一项研究旨在利用胚胎移植技术确定西门塔尔牛血小板聚集障碍的遗传模式。一头曾产下患血小板聚集障碍小牛的西门塔尔供体母牛经超数排卵后与一头同样产下患病后代的公牛交配。从移植的63枚胚胎（42.9%）中产出了27头小牛。这个略低于预期的妊娠率表明胚胎损失率有所增加。25头小牛中有23头（92%）血小板聚集模式正常，2头未显示出任何血小板聚集的迹象。数据表明遗传并非简单的孟德尔隐性遗传。更可能的情况是，该缺陷是至少两个基因遗传的结果，这也与总体人群中报告的散发病例相符。
