Ng C W, Lam M S, Paton N I
Department of Infectious Disease, Communicable Disease Centre, Tan Tock Seng Hospital, Singapore.
Singapore Med J. 2000 Feb;41(2):80-2.
Cryptococcus neoformans is the leading cause of meningitis in patients with Acquired Immune Deficiency Syndrome (AIDS) and is associated with high mortality rate. Presenting symptoms include fever, nausea and vomiting, altered mentation, headache and meningismus. Cryptococcal meningitis is not infrequently complicated by raised intracranial pressure and visual sequelae (sometimes by blindness). In patients who survive the infection, the most debilitating outcome appears to be visual impairment or blindness. Management of impending visual complication combines medical and surgical treatment modalities. We report two cases of cryptococcal meningitis associated with visual impairment.
新型隐球菌是获得性免疫缺陷综合征（AIDS）患者脑膜炎的主要病因，且死亡率高。其临床表现包括发热、恶心、呕吐、精神状态改变、头痛和颈项强直。隐球菌性脑膜炎常并发颅内压升高和视觉后遗症（有时导致失明）。在感染后存活的患者中，最使人衰弱的后果似乎是视力损害或失明。对即将出现的视觉并发症的处理需要结合药物和手术治疗方式。我们报告两例与视力损害相关的隐球菌性脑膜炎病例。
