巴西肾移植受者中TT病毒感染的患病率。
The prevalence of TT virus infection in renal transplant recipients in Brazil.
作者信息
Yokosuka O, Ikeuchi T, Kanda T, Kawai S, Imazeki F, Saisho H, Mazzalli M, Filho G A, Nishimura N F, Soares E C
机构信息
First Department of Medicine, Chiba University School of Medicine, Japan.
出版信息
Transplantation. 2000 Oct 27;70(8):1194-7. doi: 10.1097/00007890-200010270-00012.
BACKGROUND
Recently, TT virus (TTV) was discovered as a potential causative agent for non-A-E hepatitis. Little is known about the prevalence of TTV infection in renal transplant recipients.
METHODS
One hundred and seventeen Brazilian renal transplant recipients and 100 normal subjects were examined to determine the prevalence of TTV infection. The TTV DNA in serum and its genotype were examined using polymerase chain reaction and restriction enzyme length polymorphism, respectively.
RESULTS
TTV DNA was detected in 63/117 (53.8%) renal transplant recipients in contrast to its detection in 10/100 (10%) normal subjects (P<0.001). There was no statistical difference in the distribution of TTV genotypes between these groups. There was no significant difference in clinical backgrounds between TTV positive and negative patients.
CONCLUSIONS
These results indicate a risk for TTV infection in renal transplant recipients in Brazil. They also indicate that TTV itself might not have a strong correlation with the pathogenicity of liver diseases.
背景
最近，TT病毒（TTV）被发现可能是非甲-戊型肝炎的病原体。关于肾移植受者中TTV感染的流行情况知之甚少。
方法
对117名巴西肾移植受者和100名正常受试者进行检查，以确定TTV感染的流行情况。分别使用聚合酶链反应和限制性酶切片段长度多态性检测血清中的TTV DNA及其基因型。
结果
117名肾移植受者中有63名（53.8%）检测到TTV DNA，而100名正常受试者中只有10名（10%）检测到（P<0.001）。这些组之间TTV基因型的分布没有统计学差异。TTV阳性和阴性患者的临床背景没有显著差异。
结论
这些结果表明巴西肾移植受者存在TTV感染风险。它们还表明TTV本身可能与肝脏疾病的致病性没有很强的相关性。
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