Akbari H, Piroozmand A, Dadgostar E, Nikoueinejad H, Chitsazian Z, Einollahi B, Amini Mahabadi J
Department of Biostatistics and Epidemiology, Kashan University of Medical Sciences, Kashan, Iran.
Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Int J Organ Transplant Med. 2018;9(3):126-131. Epub 2018 Aug 1.
Transfusion-transmitted virus (TTV) is a single-stranded DNA virus. Renal transplant patients have a higher risk of TTV infection.
To evaluate the prevalence of TTV and its correlation with post-renal transplantation complications in a population of Iranian patients.
A cross-sectional study was performed on 120 renal transplant recipients. TTV infection in the peripheral blood samples was detected by semi-nested polymerase chain reaction (semi-nested PCR). Then, the relationship between TTV and renal post-transplant complications was examined.
34.2% renal transplant recipients were positive for TTV. There was a significant correlation between the presence of TTV and diabetes, acute transplant rejection, and urinary tract infection. We did not find any direct correlation between the presence of TTV infection and hypertension, hyperlipidemia, respiratory tract infection, and cytomegalovirus infection.
We found an increased rate of TTV infection in renal transplant recipients associated with post-transplantation complications. TTV may be an important risk factor for some post-renal transplantation complications.
输血传播病毒（TTV）是一种单链DNA病毒。肾移植患者感染TTV的风险较高。
评估伊朗患者群体中TTV的流行情况及其与肾移植后并发症的相关性。
对120名肾移植受者进行了一项横断面研究。通过半巢式聚合酶链反应（半巢式PCR）检测外周血样本中的TTV感染情况。然后，研究了TTV与肾移植后并发症之间的关系。
34.2%的肾移植受者TTV呈阳性。TTV的存在与糖尿病、急性移植排斥反应和尿路感染之间存在显著相关性。我们未发现TTV感染的存在与高血压、高脂血症、呼吸道感染和巨细胞病毒感染之间有任何直接相关性。
我们发现肾移植受者中TTV感染率增加与移植后并发症相关。TTV可能是一些肾移植后并发症的重要危险因素。
