Silber S J
Arch Surg. 1976 Jan;111(1):75-7. doi: 10.1001/archsurg.1976.01360190077014.
To determine whether the growth of a kidney is affected by the age of the host or is independently programmed, baby rat kidneys were isologously transplanted into adult rats that underwent unilateral or bilateral nephrectomies. The growth of these transplanted baby kidneys was compared to the growth of baby kidneys that were left intact in the growing baby rat. After allowing for compensatory hypertrophy, the kidneys, whether in babies or adults, were found to grow at the same rate and to the same ultimate size. Renal size could be predictably related to renal age, but not to the age of the host.
为了确定肾脏的生长是受宿主年龄影响还是独立编程的,将幼鼠肾脏同系移植到接受单侧或双侧肾切除术的成年大鼠体内。将这些移植的幼鼠肾脏的生长情况与留在生长中的幼鼠体内未受影响的幼鼠肾脏的生长情况进行比较。在考虑到代偿性肥大后,发现无论是幼鼠还是成年鼠体内的肾脏,其生长速度相同且最终大小相同。肾脏大小可预测地与肾脏年龄相关,但与宿主年龄无关。