将儿科供体肾脏移植给成年受者。是否存在关键的供体年龄？
Transplantation of pediatric donor kidneys to adult recipients. Is there a critical donor age?
作者信息
Wengerter K, Matas A J, Tellis V A, Quinn T, Soberman R, Veith F J
出版信息
Ann Surg. 1986 Aug;204(2):172-5. doi: 10.1097/00000658-198608000-00011.
Cadaver kidneys remain a scarce resource, yet single pediatric donor kidneys are underutilized at some centers. Between 1967 and 1984, 133 single pediatric and 318 adult donor cadaver transplants were performed. Patient and graft survival, renal function, and complications in adult recipients grouped by donor age were compared. Recipient age for all groups was similar (34-36 years). Life table analysis revealed no difference in graft survival in recipients of kidneys from donors aged 2, 3, 4, 5-10, and 11-15 when compared with adult donors. Graft survival in these groups improved over time with current 1-year survival over 75%. Recipients from donors less than 24 months of age demonstrated significantly poorer results, with no kidney surviving greater than 2 months. Serum creatinine of grafts functioning greater than 6 months was similar in all groups. It is concluded that single pediatric kidneys from donors greater than 2 years of age can be successfully transplanted to adults with good long-term results.
尸体肾仍然是一种稀缺资源，但在一些中心，单个小儿供体肾未得到充分利用。1967年至1984年间，共进行了133例单个小儿供体和318例成人供体尸体肾移植。对按供体年龄分组的成人受者的患者和移植物存活率、肾功能及并发症进行了比较。所有组的受者年龄相似（34 - 36岁）。生命表分析显示，与成人供体相比，2岁、3岁、4岁、5 - 10岁及11 - 15岁供体的肾移植受者的移植物存活率无差异。这些组的移植物存活率随时间有所提高，目前1年存活率超过75%。年龄小于24个月供体的受者结果明显较差，无肾存活超过2个月。所有组中功能超过6个月的移植物的血清肌酐相似。得出的结论是，年龄大于2岁的单个小儿供体肾可成功移植给成人，并取得良好的长期效果。
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