用于染色单体干涉的模型及其在重组数据中的应用。
Models for chromatid interference with applications to recombination data.
作者信息
Teuscher F, Brockmann G A, Rudolph P E, Swalve H H, Guiard V
机构信息
Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany.
出版信息
Genetics. 2000 Nov;156(3):1449-60. doi: 10.1093/genetics/156.3.1449.
Genetic interference means that the occurrence of one crossover affects the occurrence and/or location of other crossovers in its neighborhood. Of the three components of genetic interference, two are well modeled: the distribution of the number and the locations of chiasmata. For the third component, chromatid interference, there exists only one model. Its application to real data has not yet been published. A further, new model for chromatid interference is presented here. In contrast to the existing model, it is assumed that chromatid interference acts only in the neighborhood of a chiasma. The appropriateness of this model is demonstrated by its application to three sets of recombination data. Both models for chromatid interference increased fit significantly compared to assuming no chromatid interference, at least for parts of the chromosomes. Interference does not necessarily act homogeneously. After extending both models to allow for heterogeneity of chromatid interference, a further improvement in fit was achieved.
遗传干涉是指一次交叉的发生会影响其附近其他交叉的发生和/或位置。在遗传干涉的三个组成部分中，有两个得到了很好的建模：交叉的数量分布和位置。对于第三个组成部分，即染色单体干涉，只有一个模型。其在实际数据中的应用尚未发表。本文提出了一个关于染色单体干涉的新模型。与现有模型不同的是，该模型假设染色单体干涉仅在交叉附近起作用。通过将该模型应用于三组重组数据，证明了其适用性。与假设不存在染色单体干涉相比，这两个染色单体干涉模型都显著提高了拟合度，至少对于部分染色体是这样。干涉不一定均匀地起作用。在扩展这两个模型以考虑染色单体干涉的异质性之后，拟合度进一步提高。
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