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老年患者行主动脉瓣置换术伴或不伴同期冠状动脉旁路移植术:与长期生存相关的危险因素

Aortic valve replacement with and without concomitant coronary artery bypass surgery in the elderly: risk factors related to long-term survival.

作者信息

Thulin L I, Sjögren J L

机构信息

Department of Cardiothoracic Surgery, Lund University Hospital, SE-221 85 Lund, Sweden.

出版信息

Croat Med J. 2000 Dec;41(4):406-9.

PMID:11063764
Abstract

AIM

Preoperative coronary angiography often reveals significant coronary artery lesions in elderly people (>75 years of age) referred to hospital for aortic valve replacement (AVR). However, the possible benefit of concomitant coronary artery bypass grafting (CABG) in elderly is still under debate. In an effort to contribute to this discussion, we evaluated our data on elderly patients after aortic valve replacement.

METHODS

Between January 1990 and December 1993, 219 patients, aged 75 years and older, underwent AVR with or without concomitant CABG at our Department. There were 121 patients in the AVR group and 98 patients in the AVR+CABG group. There was no significant difference between the two groups in their age, sex valve type, valve size, and presence of diabetes. Five variables (concomitant CABG, age, sex, and type and size of prosthesis) were investigated with regard to long-term survival assessed by the Kaplan-Meier analysis. Group comparisons of survival were made with the Cox-Mantel log-rank test.

RESULTS

Early mortality (<30 days) was 0.8% in the AVR group and 4.1% in the AVR+CABG group. Overall actuarial survival was 77.7+/-4.4% at 52 months. There was significantly longer survival in patients with mechanical valve implant in the AVR group. None of the other 5 investigated variables had a significant influence on the long-term survival.

CONCLUSION

Our results suggest that AVR done in elderly is a treatment with excellent surgical results. We could not identify concomitant CABG as a predictor of poor long-term surgical outcome.

摘要

目的

对于因主动脉瓣置换术(AVR)而入院的老年人(年龄>75岁),术前冠状动脉造影常显示存在显著的冠状动脉病变。然而,老年患者同期进行冠状动脉旁路移植术(CABG)的潜在益处仍存在争议。为了有助于这一讨论,我们评估了我院老年患者主动脉瓣置换术后的数据。

方法

1990年1月至1993年12月期间,我院219例年龄在75岁及以上的患者接受了单纯AVR或同期AVR+CABG手术。AVR组有121例患者,AVR+CABG组有98例患者。两组在年龄、性别、瓣膜类型、瓣膜尺寸和是否患有糖尿病方面无显著差异。通过Kaplan-Meier分析评估长期生存率,研究了五个变量(同期CABG、年龄、性别、假体类型和尺寸)。采用Cox-Mantel对数秩检验进行生存组间比较。

结果

AVR组早期死亡率(<30天)为0.8%,AVR+CABG组为4.1%。52个月时的总体精算生存率为77.7±4.4%。AVR组中植入机械瓣膜的患者生存率显著更长。其他5个研究变量均未对长期生存率产生显著影响。

结论

我们的结果表明,老年患者进行AVR手术的外科治疗效果良好。我们未能确定同期CABG是长期手术预后不良的预测因素。

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