Espinet B, Solé F, Lloveras E, Abella E, Besses C, Woessner S, Florensa L
Laboratori de Citologia Hematològica/Laboratori de Referència de Catalunya, Unitat d'Hematologia 1973, Hospital del Mar, IMAS, IMIM, Barcelona, Spain.
Cancer Genet Cytogenet. 2000 Sep;121(2):194-7. doi: 10.1016/s0165-4608(00)00255-7.
We report a new dic(17;18)(p11.2;p11.2) in a 61-year-old male patient diagnosed with atypical B-cell chronic lymphocytic leukemia. The dic(17;18)(p11.2;p11.2) was detected in 90%, 10%, and 100% of metaphases in the peripheral blood, bone marrow, and lymph node, respectively. Fluorescence in situ hybridization studies with chromosome 17 and 18 centromeric probes revealed the presence of two normal centromeres of both chromosomes 17 and 18. The centromere of one chromosome 17 was found together with the centromere of one chromosome 18, confirming the dicentric nature of the rearrangement. In addition, with the use of a 17p13.1 region probe, monosomy of the 17p13 region, where the Tp53 gene is located, was observed.
我们报告了一名61岁男性非典型B细胞慢性淋巴细胞白血病患者中发现的一种新的双着丝粒染色体dic(17;18)(p11.2;p11.2)。在外周血、骨髓和淋巴结的中期细胞中，分别有90%、10%和100%检测到dic(17;18)(p11.2;p11.2)。使用17号和18号染色体着丝粒探针进行的荧光原位杂交研究显示，17号和18号染色体均存在两个正常着丝粒。发现一条17号染色体的着丝粒与一条18号染色体的着丝粒在一起，证实了这种重排的双着丝粒性质。此外，使用17p13.1区域探针时，观察到位于该区域的Tp53基因所在的17p13区域存在单体性。
