空肠弯曲菌肠炎家庭群发后发生吉兰-巴雷综合征1例。

A case of Guillain-Barré syndrome following a family outbreak of Campylobacter jejuni enteritis.

作者信息

Ang C W, van Doorn P A, Endtz H P, Merkies I S, Jacobs B C, de Klerk M A, van Koningsveld R, van der Meché F G

机构信息

Department of Neurology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands.

出版信息

J Neuroimmunol. 2000 Nov 1;111(1-2):229-33. doi: 10.1016/s0165-5728(00)00369-6.

DOI:10.1016/s0165-5728(00)00369-6

PMID:11063843

Abstract

We describe an outbreak of Campylobacter jejuni enteritis involving three family members of whom one developed Guillain-Barré syndrome (GBS). The patients' serum reacted strongly with several gangliosides and with the lipopolysaccharide (LPS) fractions from the C. jejuni strains isolated from his family members. Only low titer anti-ganglioside antibodies were found in his siblings. HLA-typing did not indicate a locus associated with auto-antibody production. Comparing the immune response in GBS patients and C. jejuni enteritis patients can be of great value in determining the additional factors that lead to post-Campylobacter GBS. Ganglioside mimicry alone is necessary but not sufficient for the induction of anti-ganglioside antibodies. Other susceptibility factors are required to induce an anti-neural immune response.

摘要

我们描述了一起空肠弯曲菌肠炎暴发事件，涉及三名家庭成员，其中一人患上了吉兰-巴雷综合征（GBS）。患者血清与几种神经节苷脂以及从其家庭成员分离出的空肠弯曲菌菌株的脂多糖（LPS）组分发生强烈反应。在其兄弟姐妹中仅发现低滴度的抗神经节苷脂抗体。HLA分型未显示与自身抗体产生相关的位点。比较GBS患者和空肠弯曲菌肠炎患者的免疫反应对于确定导致空肠弯曲菌感染后GBS的其他因素可能具有重要价值。仅神经节苷脂模拟对于诱导抗神经节苷脂抗体是必要的，但并不充分。还需要其他易感因素来诱导抗神经免疫反应。