Okuda Bungo, Koga Michiaki, Katsuta Tomoya, Okamoto Kensho, Yuki Nobuhiro
Department of Neurology, Ehime Prefectural Central Hospital, Matsuyama.
Intern Med. 2002 Oct;41(10):889-91. doi: 10.2169/internalmedicine.41.889.
A 21-year-old man developed rapid progression of tetraplegia, bulbar palsy, and respiratory paralysis after Campylobacterjejuni enteritis. Based on the diagnosis of Guillain-Barré syndrome, he received plasmapheresis and intravenous immunoglobulin. Serum anti-GT1a IgG antibody which lacked cross-reactivity with GQ1b was detected. Four months after the onset, the patient still had severe muscle weakness of the lower limbs. This case suggests that anti-GT1a IgG antibody can be associated with severe paralysis in Guillain-Barré syndrome after C. jejuni enteritis.
一名21岁男性在空肠弯曲菌肠炎后出现四肢瘫痪、延髓麻痹和呼吸麻痹的快速进展。基于吉兰-巴雷综合征的诊断，他接受了血浆置换和静脉注射免疫球蛋白治疗。检测到血清抗GT1a IgG抗体，该抗体与GQ1b缺乏交叉反应性。发病四个月后，患者下肢仍有严重肌肉无力。该病例表明，抗GT1a IgG抗体可能与空肠弯曲菌肠炎后吉兰-巴雷综合征的严重瘫痪有关。
