Filippi M
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Via Olgettina 60 - 20132, Milan, Italy.
Mult Scler. 2000 Oct;6(5):320-6. doi: 10.1177/135245850000600505.
Gadolinium-enhanced magnetic resonance imaging (MRI) is very sensitive in the detection of active lesions of multiple sclerosis (MS) and has become a valuable tool to monitor the evolution of the disease either natural or modified by treatment. In the past few years, several studies, on the one hand, have assessed several ways to increase the sensitivity of enhanced MRI to disease activity and, on the other, have investigated in vivo the nature and evolution of enhancing lesions using different non-conventional MR techniques to better define the relationship between enhancement and tissue loss in MS. The present review is a summary of these studies whose results are discussed in the context of MS clinical trial planning and monitoring. Multiple Sclerosis (2000) 6 320 - 326
钆增强磁共振成像（MRI）在检测多发性硬化症（MS）的活动性病灶方面非常敏感，已成为监测该疾病自然进展或治疗后变化的重要工具。在过去几年中，一方面，多项研究评估了多种提高增强MRI对疾病活动敏感性的方法；另一方面，利用不同的非常规MR技术对强化病灶的性质和演变进行了体内研究，以更好地界定MS中强化与组织损失之间的关系。本综述总结了这些研究，并在MS临床试验规划和监测的背景下讨论了其结果。《多发性硬化症》（2000年）6卷 320 - 326页
