Constantinescu C S, Whiteley A, Blumhardt L D
Division of Clinical Neurology, Queen's Medical Centre, University of Nottingham, Medical School Floor B, Nottingham NG7 2UH, UK.
Mult Scler. 2000 Oct;6(5):362-3. doi: 10.1177/135245850000600512.
Azathioprine is an immunosuppressive drug widely used in the treatment of chronic inflammatory diseases, including Multiple Sclerosis (MS). We report two patients who developed the first manifestations of clinically definite multiple sclerosis while on long term (3.5 and 10 years, respectively) treatment with azathioprine for Crohn's disease. Both patients developed the first MS symptoms during a quiescent phase of their inflammatory bowel disease. These cases show that long term azathioprine, while possibly maintaining inflammatory bowel disease under control, could not prevent the onset of MS. Multiple Sclerosis (2000) 6 362 - 363
硫唑嘌呤是一种免疫抑制药物，广泛用于治疗慢性炎症性疾病，包括多发性硬化症（MS）。我们报告了两名患者，他们在分别接受硫唑嘌呤长期（分别为3.5年和10年）治疗克罗恩病期间出现了临床确诊的多发性硬化症的首发症状。两名患者均在炎症性肠病的静止期出现了最初的MS症状。这些病例表明，长期使用硫唑嘌呤虽然可能使炎症性肠病得到控制，但并不能预防MS的发生。《多发性硬化症》（2000年）6卷362 - 363页
