Lejus C, Schwoerer D, Furic I, Le Moing J P, Levron J C, Pinaud M
Department of Anaesthesiology, Hôtel-Dieu, CHR Nantes, France.
Br J Anaesth. 2000 Oct;85(4):615-7. doi: 10.1093/bja/85.4.615.
No pharmacokinetic data are available with respect to the plasma concentrations and fentanyl or sufentanil during epidural administration in children. This double-blind randomized study included 12 children (5-12 yr). Patients in group F were given an epidural loading dose of fentanyl 1.5 micrograms kg-1 and in group S sufentanil 0.6 microgram kg-1. Both groups then received a continuous epidural infusion of bupivacaine 5 mg kg-1 day-1 with either fentanyl 5 micrograms kg-1 day-1 or sufentanil 2 micrograms kg-1 day-1. An epidural PCA system was also given to the children (bolus: bupivacaine 0.2 mg kg-1 and fentanyl 0.2 microgram kg-1 or sufentanil 0.08 microgram kg-1). Maximal median concentrations of plasma (0.117-0.247 ng ml-1 for fentanyl and 0.027-0.074 ng ml-1 for sufentanil) were reached approximately 30 and 20 min respectively after the loading doses. These values were similar to those measured after 48 h.
关于儿童硬膜外给药期间血浆中芬太尼或舒芬太尼的浓度，尚无药代动力学数据。这项双盲随机研究纳入了12名儿童（5 - 12岁）。F组患者接受硬膜外负荷剂量的芬太尼1.5微克/千克，S组患者接受舒芬太尼0.6微克/千克。然后两组均接受布比卡因5毫克/千克/天的持续硬膜外输注，同时分别加入芬太尼5微克/千克/天或舒芬太尼2微克/千克/天。还为儿童配备了硬膜外自控镇痛（PCA）系统（单次推注：布比卡因0.2毫克/千克和芬太尼0.2微克/千克或舒芬太尼0.08微克/千克）。负荷剂量后，血浆中芬太尼和舒芬太尼的最大中位浓度分别在约30分钟和20分钟时达到（芬太尼为0.117 - 0.247纳克/毫升，舒芬太尼为0.027 - 0.074纳克/毫升）。这些值与48小时后测得的值相似。
